Effect of corpus callosum agenesis on the language network in children and adolescents

Autor(en)

Lisa Bartha-Doehring, Ernst Schwartz, Kathrin Kollndorfer, Florian Fischmeister, Astrid Novak, Georg Langs, Harald Werneck, Daniela Prayer, Rainer Seidl, Gregor Kasprian

Abstrakt

The present study is interested in the role of the corpus callosum in the development of the language network. We, therefore, investigated language abilities and the language network using task-based fMRI in three cases of complete agenesis of the corpus callosum (ACC), three cases of partial ACC and six controls. Although the children with complete ACC revealed impaired functions in specific language domains, no child with partial ACC showed a test score below average. As a group, ACC children performed significantly worse than healthy controls in verbal fluency and naming. Furthermore, whole-brain ROI-to-ROI connectivity analyses revealed reduced intrahemispheric and right intrahemispheric functional connectivity in ACC patients as compared to controls. In addition, stronger functional connectivity between left and right temporal areas was associated with better language abilities in the ACC group. In healthy controls, no association between language abilities and connectivity was found. Our results show that ACC is associated not only with less interhemispheric, but also with less right intrahemispheric language network connectivity in line with reduced verbal abilities. The present study, thus, supports the excitatory role of the corpus callosum in functional language network connectivity and language abilities.

Organisation(en)

Institut für Psychologie der Entwicklung und Bildung

Externe Organisation(en)

Medizinische Universität Wien, Karl-Franzens-Universität Graz

Journal

Brain Structure and Function

Band

226

Seiten

701–713

Anzahl der Seiten

13

ISSN

1863-2653

DOI

https://doi.org/10.1007/s00429-020-02203-6

Publikationsdatum

01-2021

Peer-reviewed

Ja

ÖFOS 2012

302035 Kinder- und Jugendheilkunde, 501005 Entwicklungspsychologie

Schlagwörter

ASJC Scopus Sachgebiete

Allgemeine Neurowissenschaft, Anatomy, Histology

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/9567b272-4f2e-4fe2-ae7d-2212489a258f